Ischemia – reperfusion injury in human liver transplantation
نویسندگان
چکیده
............................................................................................................. 6 Original publications ...................................................................................... 7 Abbreviations .................................................................................................... 8 Introduction .................................................................................................... 10 Review of literature ....................................................................................... 12 LIVER TRANSPLANTATION ......................................................................... 12 Indications .............................................................................................. 12 Organ allocation ...................................................................................... 12 Organ donors ........................................................................................... 13 Surgery .................................................................................................... 14 Immunosuppression ................................................................................ 16 Outcome ................................................................................................. 16 DONOR INFLAMMATORY RESPONSE .......................................................... 18 LIVER ISCHEMIA-REPERFUSION INJURY .................................................... 19 Ischemia................................................................................................... 19 Reperfusion ............................................................................................. 20 “No reflow” ischemia ............................................................................... 20 Innate immunity ...................................................................................... 21 Kupffer cells ............................................................................................. 21 Neutrophils .............................................................................................. 23 Lymphocytes ............................................................................................ 26 Soluble mediators .................................................................................... 26 Graft function .......................................................................................... 29 PROTEIN C – ACTIVATED PROTEIN C PATHWAY AND INFLAMMATION .. 30 Aims of the study ........................................................................................... 33 Patients and methods ................................................................................... 34 PATIENTS AND GENERAL STUDY DESIGN ................................................... 34 CLINICAL ASSESSMENT ................................................................................ 37 Donors ..................................................................................................... 37 Recipients ................................................................................................ 37
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